Backtrace: http://wiki.vinuxproject.org/alpine_mutt

From home page:

Vinux is a Ubuntu derived distribution optimised for the needs of blind and partially sighted users. By default Vinux provides two screen-readers, Braille display support and a friendly community.
When you boot the live Vinux image, you will be greeted by the Orca screen reader enabling you to navigate the graphical Gnome desktop using keyboard commands. Finally, Brltty provides Grade 1 and 2 Braille output via Orca.

In the same category is Speakup:

The speakup project is basically a bunch of blind people who like messing around with Linux and writing cool and, hopefully useful, software.

I find this quite inspiring.